A Different Twist on Centromeric Chromatin
نویسندگان
چکیده
منابع مشابه
Sequences specify centromeric chromatin
n page 765, Ohzeki et al. present evidence for sequence specificity in assembling chromatin at mammalian centromeres. The sequence requirements imply that construction of centromeric chromatin is more than an epigenetic process. O Centromeric chromatin assembles at AT-rich repeats called ␣ satellite sequences, or alphoids. Type I alphoids contain boxes for the binding of CENP-B, one of several ...
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A fundamental requirement for life is the ability of cells to divide properly and to pass on to their daughters a full complement of genetic material. The centromere of the chromosome is essential for this process, as it provides the DNA sequences on which the kinetochore (the proteinaceous structure that links centromeric DNA to the spindle microtubules) assembles to allow segregation of the c...
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A receptor with divided loyalties T he epidermal growth factor receptor (EGFR) is caught in a tug-of-war between two membrane domains, as Lajoie et al. reveal. Which domain wins the competition for this division-promoting protein helps determine whether a cell becomes cancerous. Creating one of the domains is Caveolin1 (Cav1), which congregates in plasma membrane indentations called caveolae. C...
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ژورنال
عنوان ژورنال: Structure
سال: 2020
ISSN: 0969-2126
DOI: 10.1016/j.str.2019.12.005